In recent studies, we found that the direct PP2A activator, NSC49L, has a synergistic cytotoxicity in FOLFOX-resistant colon cancer cells both by itself and in combination with TRAIL, where the NSC49L-induced downregulation of p21 translation allowed the TRAIL-mediated increase in apoptosis [70, 131]. This evidence concerns the gene TNFSF10 and malignant colon neoplasm.