Additionally, methylation of tissue factor pathway inhibitor 2 (TFPI2) [70], XIAP associated factor 1 (XAF1) [71], Reprimo-like (RPRML) [72], multiple tumor suppressor 1 (MTS) and Cadherin 1 (CDH1) promoter region [10] dedicator of cytokinesis 10 (DOCK10), calcineurin binding protein 1 (CABIN1) and KQT-like subfamily, member 5 (KCNQ5) [73] can all be used as potential non-invasive diagnostic indicators in GC. Here, RPRML is linked to gastric cancer.