Although we had tried our best to adjust CV risk factors (including hypertension, TC, HDL-C, LDL-C, aspirin use, statins use, and insulin use) in our study, follow-up data regarding medications (such as antihypertensive agents, lipid‐modulating agents, anticoagulants and anti-diabetic drugs) were not available in this study, which possibly had impacts on CV outcomes. The gene discussed is INS; the disease is hypertensive disorder.