VIM and colorectal carcinoma: Therefore, to elucidate the potential mechanism by which PLOD3 induces cell migration and invasion, we further investigated the effect of PLOD3 on EMT-related proteins by western blot and showed that PLOD3 knockdown suppressed migration and invasion of CRC cells by attenuating EMT progression, including downregulation of VIM and upregulation of CDH1 (Fig. 3D).