PKM and hepatocellular carcinoma: Guan et al. found that a positive correlation was observed between the expression of WFDC21P and Nur77 in clinical HCC samples, which specifically assembled the promoter region of the WFDC21P to promote the expression of WFDC21P, which was significantly inhibited by interacting with both PFKP and PKM2 to inhibit glycolysis, thereby significantly inhibiting the proliferation and metastasis of liver cancer cells [65].