LncRNA RP11-386G11.10 is overexpressed in HCC, suggesting a poor prognosis.RP11-386G11.10 can act as a ceRNA that competitively binds to miR-345-3p and promotes the expression of the nuclear protein HNRNPU and downstream lipid metabolism-associated enzymes, FASN, ACC, and SCD, which leads to lipid accumulation in HCC cells and promotes HCC cells proliferation and metastasis [94]. The gene discussed is HNRNPU; the disease is hepatocellular carcinoma.