NOP58 and central nervous system cancer: For example, LncRNA INHEG is highly expressed in glioma stem cells (GSCs), enhances the interaction between NOP58 and TAF15, increases the sumoylation of NOP58, and participates in the biogenesis of the C/D box snoRNP process, as well as increases the methylation of the ribosomal RNA 2ʹ -O, and the ratio of the ribosomal RNA sites along the ribosomal RNA locus at the post-transcriptional level, which promotes the translation of the mRNAs, and maintains self-renewal of the GSCs [20].