MAFG-AS1 activates NDUFA4 through binding to miR-147b, leading to the upregulation of pyruvate dehydrogenase kinase isoform 1 (PDK1), phosphofructokinase-1 (PFK1), and PKM2, which ultimately results in the enhancement of invasive capacity and increased lactate production in CRC (colorectal cancer) cells [44]. Here, PKM is linked to colorectal cancer.