MAPT and Alzheimer disease: CSF p-tau205 displayed moderate-to-strong correlations with tau-PET SUVRs across diagnostic groups within the AD continuum, and these progressively increased in strength from CU+ (rS = 0.43, P < 0.0147) to MCI+ (rS = 0.56, P < 0.001), and from MCI+ to AD (rS = 0.64, P < 0.0001) (Supplementary Fig. 9a).