The reprogrammed cDC1-like cells engulfed tumour antigen from the TME, upregulated both MHC I complexes and costimulatory molecules, and secreted proinflammatory cytokine, such as IL-12 and IFN-γ, reverting immunostimulatory response due to tumour MHC I degradation.81 This evidence concerns the gene MPPE1 and neoplasm.