Notably, ALS has been linked to hyperactive forms of the NADase SARM1 (Gilley et al., 2021), and protective effects of nicotinamide riboside in combination with the polyphenol pterostilbene have been observed in a small trial with human ALS patients (Gilley et al., 2021), although the relative contributions of each molecule have not been resolved. This evidence concerns the gene SARM1 and amyotrophic lateral sclerosis.