This was demonstrated in vivo in flies (Huang et al. 2005) and mouse liver (Camargo et al. 2007; Dong et al. 2007) and partially explains the link between Yap abundance or activity and cancer (Kulkarni et al. 2020; Moroishi et al. 2015; Zanconato et al. 2016). Here, YAP1 is linked to cancer.