This adds YAP-driven embryonal rhabdomyosarcomas to cancers where the serine biosynthesis pathway and specifically Phgdh are highly expressed, often due to copy number gains including in breast cancer (Locasale et al. 2011; Possemato et al. 2011) and melanoma (Mullarky et al. 2011). This evidence concerns the gene PHGDH and embryonal rhabdomyosarcoma.