Other molecular alterations that have been associated with aggressive behavior and shorter survival include high tumor mutational burden and increased copy number variation load, as well as various aberrations affecting single genes or chromosomes, such as type of IDH mutation, PIK3R1 mutation, PDGFRA amplification, copy number neutral loss of 17p, loss of 19q, and others [42]. The gene discussed is IDH2; the disease is neoplasm.