We define that KEN promotes the 5′ untranslated region (5′UTR)‐dependent ADAM10 translation and alleviates amyloidogenesis in APP/PS1 mice, an animal model of AD.[17] SHMT2, which is identified as a target gene of KEN and the 5′UTR‐interacting RNA binding protein (RBP) as well, mediates the effect of KEN on ADAM10 and animal behaviors. The gene discussed is SHMT2; the disease is Alzheimer disease.