Several metabolic enzymes “moonlight” as RBPs.[49] It is reported that iron‐regulatory protein 1 binds mRNAs and regulates cellular functions.[50] Interestingly, the cytosolic SHMT (SHMT1) is shown to regulate SHMT2 by binding to the 5′UTR.[51] In our study, we provide evidence that SHMT2 binds to large numbers of RNAs that are associated with AD and multiple neurodegenerative diseases (Figure 6B), highlighting the important role of RNA processing in linking SHMT2 with the pathophysiology of AD. This evidence concerns the gene SHMT1 and Alzheimer disease.