VARs of SMAD3 were associated with pancreatitis; CNVs of PRDM1 and IL1RN were associated with irAEs; CNVs of CD274 and SLCO1B1 were associated with hepatitis; CNVs of PRDM1 and CD274 were associated with encephalitis; CNVs of PRDM1, CD274, TSHR and FAN1 were associated with myositis (univariate analysis) (72). This evidence concerns the gene SMAD3 and pancreatitis.