HLA-DRB1*04:01 was associated with high risk of irAEs (RR, 1.55; P = 0.011; HLA-DQB1*03:01 was associated with low risk of colitis (RR, 0.18; P = 0.029), and HLA-DRB1*15:01 was associated with low risk of arthralgia (P = 0.048) (81). Here, HLA-DQB1 is linked to colitis.