AOC1 and nonpapillary renal cell carcinoma: Somatic mutations were observed in 35 cases with a detection rate of 10.42% (35/336) (Fig. 1A); the highest mutation frequency was recorded for AOC1, followed by EHHADH. Since gene alterations are known to influence gene expression, we aimed to clarify the association between the mutations and expression of these 40 TMR genes in ccRCC by evaluating the expression of these 40 TMR genes in ccRCC.