Present studies show that new biomarkers of kidney injury, such as kidney injury molecule (KIM-1) or tissue inhibitor metalloproteinase 2 and insulin-like growth factor binding protein 7 (TIMP2 × IGFBP7), have the potential to be useful in the assessment of AKI, although further research is necessary to assess their usefulness in gunshot trauma patients [40, 41]. This evidence concerns the gene TIMP2 and acute kidney injury.