Furthermore, after receiving SARS-CoV-2 via intratracheal instillation, C57BL/6 mice with human angiotensin-converting enzyme 2 (hACE2) expression exhibited pathological changes in the lungs similar to human ALI/ARDS following COVID-19 infection, including bilateral congestion, pulmonary edema, and hyaline membrane formation, which had previously not been observed in other murine models [48]. Here, ACE2 is linked to acute respiratory distress syndrome.