In a recent study, an amphiphilic copolymer poly(β-amino esters)-polyethene glycol (PAE-PEG) was used to entrap the hydrophobic (2-[(aminocarbonyl)-amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide (TPCA-1), and the biotinylated PEG were further conjugated to avidin-tagged intercellular adhesion molecule-1 (ICAM-1) antibody for lung endothelium targeting in LPS-nebulized ALI mice, where pH-sensitive PAE degraded upon acidic environment in inflamed lungs and thus released TPCA-1 to quench the cytokine production [178]. The gene discussed is ICAM1; the disease is acute respiratory distress syndrome.