While several previous studies indicated that the sensitivity extent of metastatic melanoma [84], non-small-cell lung cancer [11], and urothelial carcinoma [16] to ICIs correlates with the PD-L1 status, another study failed to report a differential sensitivity pattern with respect to PD-L1 expression level in renal carcinoma [13]. The gene discussed is CD274; the disease is renal carcinoma.