In order to select the robust features, we took the intersection features of the three sets of top 10 important features as the variables for constructing the TRM-SIS and finally screened out six important features: density of CD103+ cells in TC, density of TRM3 in IM, InS of Tnon-RM in TC, InS of TRM1 in IM, InS of TRM4 in IM and mNND from TRM to cancer cells in TC (Fig. 3D, E). This evidence concerns the gene NSUN2 and cancer.