A multicenter study of patients undergoing revision total joint arthroplasty examined elevated serum C-reactive protein (CRP > 1 mg/dL), D-dimer (> 860 ng/mL), and erythrocyte sedimentation rate (> 30 mm/h), which were assigned 2, 2, and 1 points, respectively, and jointly constructed a new standard for the diagnosis of periprosthetic infection (PJI) with other laboratory indicators; its sensitivity and specificity were significantly higher than those of the Musculoskeletal Infection Association and International Consensus Conference Definition [40]. Here, CRP is linked to juvenile polyposis syndrome.