Multiple studies, using genetic and pharmacological approaches, have demonstrated the regulation of inflammatory response by PRR: deletion of PRR reduced ocular inflammatory molecules expression and macrophage infiltration in diabetic mice, while overexpression of PRR markedly increased macrophage infiltration and proinflammatory cytokine level in abdominal aortic aneurysm [32–34]. The gene discussed is ATP6AP2; the disease is abdominal aortic aneurysm.