TGFB1 and diabetic kidney disease: Furthermore, novel pathways have been proved play significant roles in aggravating the progression of DKD such as TGFβ signaling, WNT signaling, Notch signaling and Hedgehog signaling, or providing protective effect in halting DKD process such as endothelial glucocorticoid receptor, FGFR1 and SIRT3-mediated mechanisms in mouse model of DKD [4, 9, 11–13].