These pathways included the Toll-like receptor, mTOR, AMPK, FoxO, B cell receptor, Jak-STAT, cAMP, Apoptosis, T cell receptor, TNF, Chemokine, PPAR, MAPK, Notch, PI3K-Akt, ErbB, Rap1, cGMP-PKG, VEGF, Calcium, Wnt, NF-κB, Ras, Hippo, Prion diseases, and Fc epsilon RI signaling pathway. Here, TNF is linked to prion disease.