Expression profiles of differentially expressed genes included: cycling cells (TOP2A, MKI67), fibroblasts (GATA3, FLRT2), synthetic fibroblasts (synthetic) (COL1A1, PCOLCE, SPARC, IGFBP7), and cancer associated fibroblasts (CAFs) (CCL2, CXCL8, MMP2) (Additional file 1: Fig. A3C, Additional file 4: Table S3). The gene discussed is TOP2A; the disease is cancer.