SCUBE2 (Fig. 5e and Extended Data Fig. 7b), B4GALT1 (Fig. 5f and Extended Data Fig. 7c) and MYO3B (Extended Data Fig. 7d) genes also exemplify the relationship between decitabine-induced gain of multiple ER-bound enhancer–promoter interactions and activation of their ER target genes that are associated with good prognosis in ER+ breast cancer. Here, ESR1 is linked to breast carcinoma.