REN and diabetic kidney disease: High succinate levels in the urine of individuals with progressive diabetic nephropathy [45] and of murine models of streptozocin-induced type 1 diabetes [43], along with high glucose driving increased renin and prorenin release via activation of the succinate–SUCNR1 pathway [43], underscore this significance of the succinate–SUCNR1 axis in the pathophysiology of diabetic nephropathy.