The myeloid receptor, TREM2, has garnered scientific attention due to its association with the risk of Alzheimer’s disease [24], as well as its roles in chronic diseases as a pathology-induced immune signaling pathway in macrophages [8], such as promoting phagocytosis, maintaining metabolic homeostasis and preserving cell survival [25]. This evidence concerns the gene TREM2 and early-onset autosomal dominant Alzheimer disease.