Moreover, PAF1 knockdown decreased the expression levels of the genes such as LGR5, ID1, ID3, CD44v9, CD133, BMI1, RNF43, EPHB2, SOX9, and ASCL2 (Fig. 2B and Supplementary Fig. 2A), which are critical for inducing colon cancer stemness and its markers [5, 16]. Here, BMI1 is linked to malignant colon neoplasm.