CCHFV infection of these reconstituted cells showed that the full-length LDLR restored CCHFV infectivity as determined by comparable levels of NP expression (Fig. 2b), S segment mRNA (Fig. 2c), percentage of Gn-positive cells (Fig. 2d), cytopathic effects (Fig. 2e) and progeny virus production (Fig. 2f) with control edited SW13 cells which express endogenous LDLR. Here, LDLR is linked to infection.