Given our recent insights that introduction of the GoF variant of CXCR4, CXCR4R334X, to NK cells results in that they also respond to low levels of the SDF-1α [19], we hypothesized that CXCR4R334X overexpression would help them better infiltrate AML-containing BM compartments with low SDF-1α levels. This evidence concerns the gene CXCR4 and acute myeloid leukemia.