SELE and acute myeloid leukemia: As AML progression was shown to gradually reduce BM SDF-1α levels, recapitulating what is observed in patients [24, 25], while increasing E-selectin+ BMECs, we explored the potential of modifying ex vivo expanded human NK cells to express FUT7 for intrinsic forced fucosylation along with GoF CXCR4R334X to better sense suppressed SDF-1α levels.