Consistently, we observed significantly higher IL-6 levels in primary Mettl3 cKO BMDM compared to Mettl3 WT BMDM following infection with P. multocida and S. aureus for 0–12 h, and M. pneumoniae for 0–24 h (Appendix Fig. S12D), as well as TNF-α (Appendix Fig. S12E). This evidence concerns the gene METTL3 and infection.