Our findings differ from those reporting that METTL3 initiates m6A modifications on TLR4 mRNA to promote its protein expression during neutrophil activation (Luo et al, 2023), suggesting that we discovered a novel function for the DDX5-METTL3-METTL14 complex via YTHDF2 to regulate the transcription of TLR2/4 mRNA during bacterial infection, which sheds light on mechanisms regulating the switch between inflammation and homeostasis. Here, METTL3 is linked to bacterial infectious disease.