In our study, TLR4 and TLR2 transcripts were themselves m6A-modified following LPS, FSL-1, or Pam3CSK4 treatment in a DDX5-dependent manner; this is the first study to report that the TLR2/TLR4 transcripts could be regulated by post-transcriptional epigenetic modifications during bacterial infection. This evidence concerns the gene TLR2 and bacterial infectious disease.