Unlike DHX29 or DDX19A, which act as viral RNA sensors and activators of inflammation through the NF-κB or NLRP3 pathways (Li et al, 2015; Zhu et al, 2018), DDX5 regulates the m6A modification of TLR2/4 mRNA to suppress inflammatory responses pathway during bacterial infection. Here, DDX5 is linked to bacterial infectious disease.