METTL3 and infection: However, several studies have reported that the m6A modification affected the inflammatory response in different diseases (Zheng et al, 2017; Jian et al, 2020; Mapperley et al, 2021; Wang et al, 2021); therefore, we further confirmed the specificity for DDX5-mediated m6A-modified regulation of inflammatory response in Mettl3 cKO mice after infection with pathogenic bacteria.