RCAN3 and peripheral arterial disease: Batan et al. show that inhibiting the antiangiogenic VEGF165b isoform activates a previously unrecognized miR-17-20a-RCAN3 pathway that induces ischemic endothelial cell angiogenic capacity and promotes M2-like macrophage polarization to achieve perfusion recovery in murine peripheral artery disease (PAD) model.