Landskroner-Eiger et al.28 have shown improved limb arteriogenesis in EC-specific miR-17-92 cluster-deficient mice in experimental PAD, and this study shows that specific targeting of Frizzled Class Receptor 4 (FZD4) and LDL Receptor Related Protein 6 (LRP6) by miR-19 within the cluster plays a causal role in decreasing blood flow recovery28. Here, LRP6 is linked to peripheral arterial disease.