IL6 and obesity due to melanocortin 4 receptor deficiency: The significant increase in IL-6 (p = 0.008, Fig. 1A) and MDA levels (p = < 0.001, Fig. 1B), along with the decreasing tendency of the endogenous antioxidant GSH (p = 1.0, Fig. 1C) and catalase (p = 0.900, Fig. 1D) in the obese control group compared to the control group, proved that obesity-induced high-fat diet leads to an increased stress state due to persistent uneliminated oxidants in the brain.