CXCL12 and neoplasm: Compared to low-stromal tumor samples, CA-MSCs, fibroblasts, and myofibroblasts from high-stromal samples showed higher expression of immunosuppressive cytokines, including CXCL8 and CXCL12, and the fibroblast growth factor receptor FGFR1, which is involved in tumor growth and angiogenesis25 (Fig. 2a, Fig. S3a).