We, indeed, found that the phosphorylation of Akt was decreased in TAMs fraction of tumours that were excised from mice receiving δD910A/D910A macrophages compared to that observed in mice receiving WT macrophages (Fig. 1e and Supplementary Fig. 8) as well as in TAMs fraction of tumours that were excised from mice treated with IC87114 compared to that found in mice that were treated with vehicle (Fig. 1f and Supplementary Fig. 8). Here, AKT1 is linked to neoplasm.