The intratumoural injection of p190RhoGAP siRNA in 451Lu tumours suppressed the expression of p190RhoGAP (Supplementary Figs. 5a and 13a) and induced the activity of RhoA (Supplementary Figs. 5b and 13b) and PTEN (Supplementary Fig. 5c) whereas suppressed the phosphorylation of Akt (Supplementary Figs. 5d and 13d). This evidence concerns the gene AKT1 and neoplasm.