ARHGAP35 and neoplasm: Interestingly, when intratumoural p190RhoGAP siRNA injections in B16 tumours was combined with adoptive transfer of δD910A/D910A macrophages into B16 tumour-bearing NSG mice there was an almost complete blockade of tumour growth compared to mice receiving WT macrophages alone or WT macrophages and p190RhoGAP siRNA injections (Fig. 2a).