Furthermore, the tumour mass (Fig. 4b) as well as the number of tumour cells in the blood (Fig. 4c) were almost completely blocked in 451Lu-tumour bearing mice receiving p190RhoGAP siRNA and δD910A/D910A macrophages confirming that the efficacy of this treatment approach is independent on BRAF mutational status of the tumour cells. This evidence concerns the gene BRAF and neoplasm.