We next explored the potential positive impact of oral administration of the ATX inhibitor PF-8380 (4-[3-(2, 3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-(3, 5-dichlorophenyl)methyl ester-1-piperazinecarboxylic acid) or vehicle on tumour growth. Here, ENPP2 is linked to neoplasm.