In this study, we analyzed the somatic mutation of colon cancer samples from the TCGA database and found that the top ten mutated genes in colon cancer samples were APC, TP53, TTN, KRAS, PIK3CA, SYNE1, MUC16, FAT4, ZFHX4 and OBSCN. This evidence concerns the gene ZFHX4 and colonic neoplasm.