In this study, we analyzed the somatic mutation of colon cancer samples from the TCGA database and found that the top ten mutated genes in colon cancer samples were APC, TP53, TTN, KRAS, PIK3CA, SYNE1, MUC16, FAT4, ZFHX4 and OBSCN. The gene discussed is ZFHX4; the disease is malignant colon neoplasm.