In this study, we analyzed the somatic mutation of colon cancer samples from the TCGA database and found that the top ten mutated genes in colon cancer samples were APC, TP53, TTN, KRAS, PIK3CA, SYNE1, MUC16, FAT4, ZFHX4 and OBSCN. Here, FAT4 is linked to malignant colon neoplasm.