In order to identify the correlation of 4 lysosome-related lncRNA signature with tumor immune response, we assessed the correlation between the risk score and 22 types of tumor infiltrating immune cells (TIICs) in colon cancer and showed that the expression of the CD4 memory resting T cells in the high- risk group was lower than that of the low- risk group. Here, CD4 is linked to malignant colon neoplasm.