Reanalysis of prior PBMC RNA-seq data on influenza vaccine responses in younger adults showed upregulated expression of IGHG1 and IGHG3 at day 7, whereas pneumococcal vaccines upregulated the expression of IGHA2 and IGHG2 (Fig. 2d and Extended Data Fig. 3c). The gene discussed is IGHG2; the disease is influenza.