Together, transcriptional profiling before and after vaccination revealed that both pneumococcal vaccines induced significant and similar plasmablast responses 10 d after vaccination, including increased transcription of genes encoding IgG2 and IgA2 antibody isotypes, contrasting with those (IgG1, IgG3 and IgA1) induced by the influenza vaccine. This evidence concerns the gene IGHG3 and influenza.