In particular, EPS8, encoding for the Epidermal Growth Factor Receptor Pathway Substrate 8, and FRMD4A, that encodes for FERM Domain Containing 4 A, have been recently associated with Alzheimer’s disease; 15,16ARL6IP1, encoding for ADP Ribosylation Factor Like GTPase 6 Interacting Protein 1, has been associated with hereditary spastic paraplegia;17 and PIAS1, that encodes for Protein Inhibitor Of Activated STAT 1, has been implicated in Huntington’s disease18. Here, PIAS1 is linked to early-onset autosomal dominant Alzheimer disease.