CD276 and neoplasm: Given the conflicting functional data obtained for B7-H3 between murine and human species in which the dominant isoform differs between 2Ig and 4Ig, respectively, additional studies across species will be required to decipher the role of dimerization on isoform-specific functional consequences on both the tumor intrinsic functions (cis) as well as roles to modulate tumor extrinsic function, including the immune system.