AR and hepatocellular carcinoma: Among HCC patients, seven types of hepatic AR missense mutations have been reported, including Q62L/Q63L/Q64L (9/366), E81Q (1/366), A188D (1/366), T440A (1/366), G489R (1/366), C602Y (1/366), and S815N (1/366) (Fig. 1c).