Checking the rules identified by the CBA algorithm in Table 2; duration of diabetes more than 10 years, insulin therapy, male sex, older age, being a smoker, addiction to other drugs, family history of diabetes, higher body mass index, physical inactivity, having proliferative, non-proliferative retinopathy, nephropathy, history of heart or kidney disease, level of LDL, HDL cholesterol, triglyceride (TG), systolic and diastolic blood pressure, BS2HPP and experience of cardiovascular events are effective in the occurrence of diabetic foot ulcer. This evidence concerns the gene INS and diabetes mellitus.