Based on the results of the multiple regression model; duration of diabetes more than 10 years, insulin therapy, male sex, addiction to other drugs, family history of diabetes, higher body mass index, having non-proliferative retinopathy, nephropathy, history of heart or kidney disease, higher level of LDL cholesterol, HDL cholesterol, triglyceride (TG), significantly increase the chance of occurrence of diabetic foot ulcer. Here, INS is linked to diabetes mellitus.