Our research group previously reported that treatment with selenoprotein P (SeP; SELENOP, encoded by the SELENOP gene) siRNA resulted in a ferroptosis-like cell death in insulinoma MIN6 cells21, and a recent study also indicated that neuroblastoma, a neuronal tumor, requires SeP as a selenium source to confer resistance against ferroptosis through GPX4 expression22. This evidence concerns the gene SELENOP and pancreatic insulinoma.