In this study, CSF ANGPT-2 level was highest in MCI patients and correlated with CSF albumin and sPDGFRβ, a marker of pericyte injury that was previously shown to be elevated in early AD (clinical dementia rating 0.5) and to correlate with MRI evidence of BBB breakdown within the hippocampus [22, 23]. The gene discussed is ANGPT2; the disease is dementia.