ANGPT2 and Alzheimer disease: In this study, we show elevated CSF ANGPT-2 levels in individuals with CSF biomarker positivity for AD, based on established cut-off values for t-tau, p-tau181 and Aβ42 [26], which correlated with CSF t-tau and p-tau181, and with markers of pericyte injury (sPDGFRβ) and BBB leakiness (CSF fibrinogen).