Elevation of ANGPT-2 is likely to occur early in the development of disease - in an independent cohort spanning the full spectrum of cognitive decline in AD, CSF ANGPT-2 was highest in MCI and correlated most strongly with CSF albumin level in the cognitively unimpaired (CU) and MCI groups compared to AD, despite CSF albumin levels continuing to rise with disease progression. This evidence concerns the gene ANGPT2 and Mental deterioration.