A recent study revealed that CSF sPDGFRβ level correlated positively with the CSF/serum albumin ratio, a marker of BBB leakiness, in patients with clinical dementia rating between 0 and 0.5 but not in established AD [5]; the CSF/serum albumin ratio rose steadily with disease progression, as we found for CSF albumin in the present study. This evidence concerns the gene ALB and Alzheimer disease.