ANGPT-2 was recently shown to be elevated in cortical neurones in young 2-month old J20 mice with evidence of pathological angiogenesis and was induced in response to Aβ peptides in neural stem cells suggesting that Aβ-induced ANGPT-2 expression within neurons contributes to vascular instability in early AD [25]. This evidence concerns the gene ANGPT2 and Alzheimer disease.