In this study, we have explored the relationships between CSF ANGPT-2; markers of pericyte injury (CSF sPDGFRβ) and BBB leakiness (CSF fibrinogen and albumin); established markers of core AD pathology (CSF Aβ and tau); and markers of neuronal injury (neurogranin and α-synuclein) and neuroinflammation (GFAP and YKL-40), in three independent cohorts. The gene discussed is NRGN; the disease is Alzheimer disease.