In this study, our results showed increases in PD-L1 expression on cancer cells (Fig. 6G, H and Fig. S3F–H, S4E), induction of neoantigen expression (Fig. 6A and Fig. S3A, S4A), upregulation of MHC and antigen-processing genes (Fig. 6B–F and Fig. S3B–E, S4B–D), and rendering immunologically cold breast cancer higher sensitivity to ICB (Fig. 6I–K and Fig. S5). This evidence concerns the gene CD274 and cancer.