Consistent with previous work [29], tdTomato-positive cells expressing Osterix were also detected in the bone marrow (BM) of young non-tumor-bearing mice, as validated by immunofluorescence of bone-frozen sections (Fig. 1D) and flow cytometry analysis of BM cells representing the percentage of tomato-positive cells in the BM of 2-months old mice (10.2%) (Fig. 1E). This evidence concerns the gene SP7 and neoplasm.