CXCL12 and neoplasm: Specially, iCAFs interacted with tumor-infiltrating T cells through CXCL9/10/11-CXCR3, CXCL12-CXCR4, and CCL19-CCR7, suggest that these iCAFs might recruit T cells and shape the immune landscape of AEG TME through multiple chemotactic regulation (Fig. 5C).