MYC and neoplasm: GSVA analysis revealed the predominant enrichment of inflammatory response, IL10 pathway, EMT, tumor invasion, and cytokine pathway in iCAFs, and Myc, myogenesis, angiogenesis, TGFβ signaling, metastasis, and hypoxia in myCAFs (Fig. 4E), suggesting their critical roles on tumor development for AEG in different manners.