Glutathione transferase Omega-1 (GSTO1) can prevent azomethane induced colorectal tumor formation through Omega like glutathione transferase GSTO1-1 regulation of the pro-inflammatory cytokine IL-1 by removing the protective cellular mechanisms of NEK7 in NLRP3 inflammasomes, stimulation of β release of IL-18 and protection against CRC formation. This evidence concerns the gene GSTO1 and colorectal neoplasm.