It has been shown that NLRP3-mediated activation of interleukin (IL)-18 and IL-1β is responsible for macrophage stimulation of interferon genes’ (STING) signaling and the promotion of 4-1BBL/4-1BBL-dependent natural killer (NK) cell anti-tumor properties thereby inhibiting the metastatic growth of CRC in the liver [11, 12]. This evidence concerns the gene IL18 and colorectal carcinoma.