Given the pervasive importance of thromboinflammation driving critical illness and injury, the results of our work are relevant to other coagulation and inflammation disorders as well, including hemophilia, von Willebrand disease, factor V Leiden, pulmonary embolism, deep vein thrombosis, stroke, sickle cell disease, cancer, and COVID-19. This evidence concerns the gene F5 and platelet-type von Willebrand disease.