A similar effect on PARP14 expression and survival was seen in PARP9, DTX3L and PARP14 depleted HeLa and BxPC3 PAAC cell lines and it is possible that overexpression of PARP9 and PARP14 is a common survival pathway in a variety of cancer cells, in addition to metastatic prostate cancer cell lines previously reported.19 The gene discussed is PARP14; the disease is cancer.