NRG1 and brain disorder: Akt1, which has been implicated in other brain disorders and contributed to the impairment of synaptic plasticity (94), is a well-established effector for neuregulin1 (NRG1–ERBB4–PI3K–AKT1 signaling cascade) pathway, and NRG1, via the ErbB4 receptor, prevented the Aβ1-42–induced impairment of LTP in hippocampal slices (95).