Nevertheless, given the broad predictive power of our biomarker, and the fact that the Ly6Ehi phenotype is induced by IFN, localized IFN activity in the tumor microenvironment may prove to be a crucial and common step in the mechanism of immunotherapy response regardless of the exact source of IFN or the exact IFN involved in a given case (IFNα or IFNγ).43 This evidence concerns the gene IFNG and neoplasm.