CD274 and cancer: Remarkably, Ly6Ehi neutrophils stratify between non-responder and responder groups (AUC ≈ 0.9) in both cancer types, whereas pre-existing biomarkers, namely, PDL1 IHC and total neutrophil count measured in the same group of patients with NSCLC, underperformed (AUC ≈ 0.6 and 0.75, respectively) (Figure 6F).