The myeloid cells, key regulators of anti-tumor immunity due to their roles in antigen presentation, T cell polarization and immunosuppression,27 consisted of mast cells, plasmacytoid dendritic cells (pDC), conventional DC (cDC), S100A8/A9hi undifferentiated monocytes (Mo), and four differentiated macrophage populations (IL10hi, CCL2hi, APOhi, and MAFhi macrophages [Mφ; Figure 2B]). The gene discussed is S100A8; the disease is neoplasm.