CD8A and neoplasm: After treatment however, αβ (CD8+ and CD4+) T cell subsets shared a significantly increased expression of eight genes (Figures 4M, S5G, and S5H), of which transcription factors MAF and TSC33D3, as well as MYADM and ZFP36 were previously associated with dysfunction of T cells in tumor-microenvironments and/or repression of T cell activation.33