In opposition to the expression pattern of KANSL1, decreased expression of KAT8 is associated with deacetylation of H4K16ac in AD patients, while an overexpression of KAT8 has been linked to increased expression levels of neuroprotective soluble amyloid precursor protein (sAPP)α and β-secretase (BACE)2 and decreased levels of sAPPβ and BACE1 (MIM: 604252).55 This evidence concerns the gene BACE1 and Alzheimer disease.