KAT8 and ischemic stroke: However, compound MG149, a histone acetyltransferase inhibitor, has been found to reduce proinflammatory genes via inhibition of MYST (named for protein members MOZ, Ybf2/Sas3, Sas2, and Tip60)-type histone acetyltransferase KAT8. 58MG149 has also been found to be effective in restoring impaired autophagic flux via the inhibition of histone acetylation of H4K16ac in cases of ischemic stroke and inflammatory diseases.48